Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.83 |
| ▸ | TSHR | P16473 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247337 | 0.91 | SMN1; SMN2 (1.00) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL5492983 | 0.81 | NOTUM (0.64) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL29449723 | 0.81 | NOTUM (1.00) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL396037 | 0.81 | NOTUM (1.00) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL29611497 | 0.80 | NOTUM (0.62) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL10899996 | 0.80 | NOTUM (0.62) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL27881451 | 0.79 | NOTUM (0.61) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL29449730 | 0.79 | ALDH1A1 (0.71) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL789554 | 0.79 | ALDH1A1 (0.71) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 | |
| SCHEMBL11981335 | 0.78 | NOTUM (0.68) | KMT2ASMN1; SMN2TSHRMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015516-A1 | FUSED TRICYCLIC HETEROCYCLES FOR THE TREATMENT OF SCHIZOPHRENIA | PFIZER PRODUCTS INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| EP-1546143-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | ANDREANA TONJA LYNN (US) | 2004-07-15 | — | — | US | disclosed |
| WO-2004026864-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | CNR1, DRD2, CNR2 | KMT2A 480/4885SMN1; SMN2 1623/4885TSHR 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.