Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548617 | 0.92 | GRIA3 (0.53) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10032960 | 0.79 | GRIA3 (0.60) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548613 | 0.79 | GRIA3 (0.50) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL15458881 | 0.77 | RAB9A (0.40) | RAB9ANPC1KMT2APRMT5WDR77 | |
| SCHEMBL548631 | 0.76 | GRIA3 (0.53) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548676 | 0.76 | GRIA3 (0.59) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8107107 | 0.75 | GRIA3 (0.56) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL637281 | 0.75 | GRIA3 (0.55) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548627 | 0.74 | GRIA3 (0.51) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL549483 | 0.74 | GRIA3 (0.51) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240100023-A1 | Compositions and Methods For Treating Spinal Cord Injuries | LIPPA ARNOLD S (US) | 2024-03-28 | — | — | US | claimed |
| US-20230373982-A1 | Compositions And Methods For Treating Attention Deficit Disorders | LIPPA ARNOLD STAN (US) | 2023-11-23 | — | — | US | claimed |
| US-8263591-B2 | Bicyclic amides for enhancing glutamatergic synaptic responses | CORTEX PHARMACEUTICALS, INC. (US) | 2012-09-11 | — | — | US | claimed |
| US-8110584-B2 | Methods for the treatment of respiratory depression | Cotex Pharmaceuticals, Inc. (US) | 2012-02-07 | — | — | US | claimed |
| US-20110003835-A1 | Methods for the treatment of respiratory depression | CORTEX PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | claimed |
| US-20230373982-A1 | Compositions And Methods For Treating Attention Deficit Disorders | LIPPA ARNOLD STAN (US) | 2023-11-23 | — | — | US | disclosed |
| US-20190112300-A1 | Compositions And Methods For Treating Attention Deficit Disorders | LIPPA ARNOLD STAN (US) | 2019-04-18 | — | — | US | disclosed |
| US-9492440-B2 | Bicyclic amides for enhancing glutamatergic synaptic responses | RESPIRERX PHARMACEUTICALS INC (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492440-B2 | Bicyclic amides for enhancing glutamatergic synaptic responses | RESPIRERX PHARMACEUTICALS INC (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492440-B2 | Bicyclic amides for enhancing glutamatergic synaptic responses | RESPIRERX PHARMACEUTICALS INC (US) | 2016-11-15 | — | — | US | disclosed |
| EP-2187888-B1 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMA INC (US) | 2015-10-21 | — | — | EP | disclosed |
| US-20130190351-A1 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-8110584-B2 | Methods for the treatment of respiratory depression | Cotex Pharmaceuticals, Inc. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20110003835-A1 | Methods for the treatment of respiratory depression | CORTEX PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003835-A1 | Methods for the treatment of respiratory depression | CORTEX PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003835-A1 | Methods for the treatment of respiratory depression | CORTEX PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20100286177-A1 | BICYCLIC AMIDES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | CORTEX PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286177-A1 | BICYCLIC AMIDES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | CORTEX PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286177-A1 | BICYCLIC AMIDES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | CORTEX PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| EP-2233140-A1 | Bicyclic amides for enhancing glutamatergic synaptic responses | Biovail Laboratories International SRL (BB) | 2010-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240100023-A1 | Compositions and Methods For Treating Spinal Cord Injuries | CHAT, NTRK2, GMFG | GRIA3 38/4885GRIA4 37/4885TAS1R3 4607/4885 |
| US-20130190351-A1 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | BDNF, GRIN2A, SLC18A2 | GRIA3 17/4885GRIA4 23/4885TAS1R3 2813/4885 |
| US-20110003835-A1 | Methods for the treatment of respiratory depression | BDNF, CHRNA10, CHRNA3 | GRIA3 93/4885GRIA4 246/4885TAS1R3 3140/4885 |
| US-20100286177-A1 | BICYCLIC AMIDES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | BDNF, HCRTR2, CHRNA10 | GRIA3 165/4885GRIA4 436/4885TAS1R3 2966/4885 |
| US-20230373982-A1 | Compositions And Methods For Treating Attention Deficit Disorders | GRIN2A, GRIN2C, GRM2 | GRIA3 32/4885GRIA4 38/4885TAS1R3 4030/4885 |
| US-20190112300-A1 | Compositions And Methods For Treating Attention Deficit Disorders | GRIN2A, GRIN2C, GRM2 | GRIA3 32/4885GRIA4 38/4885TAS1R3 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.