SCHEMBL5493492

SCHEMBL5493492

NCCC1CNc2ccc(F)cc21

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 1/20 0.39
KDM1A O60341 2/20 0.38
KDM1B Q8NB78 1/20 0.38
SLC6A2 P23975 4/20 0.37
SLC6A4 P31645 4/20 0.37
SLC6A3 Q01959 3/20 0.37
CHRNB2 P17787 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA4 P43681 1/20 0.37
HTR2A P28223 2/20 0.36
HTR2C P28335 2/20 0.36
HTR2B P41595 1/20 0.36
HTR7 P34969 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13349413 0.87 HTR2A (0.40) KDM1AKDM1BSLC6A2SLC6A4SLC6A3
SCHEMBL3956308 0.84 TACR2 (0.39) TACR2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL29572531 0.84 TACR2 (0.39) TACR2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL3956306 0.84 TACR2 (0.39) TACR2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8260934 0.84 TACR2 (0.39) TACR2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL14724849 0.81 CHRNB2 (0.37) SLC6A2SLC6A4CHRNB2CHRNA4HTR2A
SCHEMBL3597607 0.81 CHRNB2 (0.37) SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4
SCHEMBL26602774 0.80 TACR2 (0.38) TACR2SLC6A4CHRNB2CHRNB4CHRNA3
SCHEMBL31377482 0.80 TACR2 (0.38) TACR2SLC6A4CHRNB2CHRNB4CHRNA3
SCHEMBL14294999 0.80 TACR2 (0.41) TACR2CHRNB2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658267-A4 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2007-08-01 EP disclosed
EP-1658267-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2006-05-24 EP disclosed
WO-2005034848-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2005-04-21 WO disclosed
WO-2004112709-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2004-12-29 WO disclosed