Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | HTR2C | P28335 | 7/20 | 0.36 |
| ▸ | HTR2B | P41595 | 7/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493492 | 0.81 | TACR2 (0.39) | CHRNB2CHRNA4HTR2AHTR2CHTR2B | |
| SCHEMBL3597607 | 0.81 | CHRNB2 (0.37) | CHRNB2CHRNA4HTR2AHTR2CHTR1A | |
| SCHEMBL27759103 | 0.80 | HTR2C (0.55) | CHRNB2CHRNA4HTR2AHTR2CHTR2B | |
| SCHEMBL7448411 | 0.77 | HTR2A (0.39) | HTR2AHTR2CHTR2B | |
| SCHEMBL12115566 | 0.77 | HTR2C (0.37) | CHRNB2CHRNA4HTR2AHTR2CHTR2B | |
| SCHEMBL11473137 | 0.76 | IDO1 (0.45) | HTR2AHRH1 | |
| SCHEMBL29558888 | 0.76 | IDO1 (0.45) | HTR2AHRH1 | |
| SCHEMBL14135873 | 0.74 | CNR1 (0.34) | HTR2AHTR2CHTR2BCNR1 | |
| SCHEMBL14315843 | 0.74 | PNMT (0.35) | — | |
| SCHEMBL19187434 | 0.73 | ADRA2A (0.38) | HTR2CADRB1HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240483-B1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2013-02-27 | — | — | EP | disclosed |