Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31171398 | 0.92 | TRPV4 (0.47) | TRPV4CYP11B2DGAT1ROCK2KHK | |
| SCHEMBL8300964 | 0.82 | TRPV4 (0.48) | TRPV4 | |
| SCHEMBL811340 | 0.81 | DGAT1 (0.58) | DGAT1ROCK2CASP1PARP10PARP15 | |
| SCHEMBL8004361 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2KHKCYP11B1PDE4A | |
| SCHEMBL8006776 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2KHKCYP11B1PDE4A | |
| SCHEMBL8299340 | 0.81 | TRPV4 (0.47) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL7752581 | 0.78 | TRPV4 (0.44) | TRPV4CYP11B2KHKCYP11B1PDE4A | |
| SCHEMBL2323641 | 0.77 | DGAT1 (0.54) | CYP11B2DGAT1ROCK2CASP1PARP10 | |
| SCHEMBL15920675 | 0.77 | GAA (0.44) | TRPV4 | |
| SCHEMBL410466 | 0.77 | GAA (0.48) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656360-B1 | THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| EP-1656360-A1 | THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-17 | — | — | EP | disclosed |
| US-20050014952-A1 | Novel thiazoline derivatives as selective androgen receptor modulators (SARMS) | JASSEN PHARMACEUTICA N.V. (BE) | 2005-01-20 | — | — | US | disclosed |
| WO-2004113309-A1 | THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014952-A1 | Novel thiazoline derivatives as selective androgen receptor modulators (SARMS) | AR, NR5A1, NR5A2 | TRPV4 665/4885CYP11B2 31/4885DGAT1 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.