Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGAV | P06756 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501542 | 0.84 | KDM4A (0.39) | KDM4ANAAAPOLBHPGDITGB3 | |
| SCHEMBL5501061 | 0.80 | ITGB3 (0.46) | HPGDITGB3ITGAV | |
| SCHEMBL5495303 | 0.79 | CHRNB2 (0.50) | — | |
| SCHEMBL5492131 | 0.77 | CHRNB2 (0.46) | — | |
| SCHEMBL5496941 | 0.77 | CHRNB2 (0.46) | — | |
| SCHEMBL5504521 | 0.74 | ITGB3 (0.39) | POLBITGB3ITGAVGAARET | |
| SCHEMBL5502048 | 0.74 | ITGB3 (0.39) | POLBITGB3ITGAVGAARET | |
| SCHEMBL5159894 | 0.72 | MEN1 (0.46) | HPGDGAA | |
| SCHEMBL5495127 | 0.72 | PROC (0.38) | HPGDITGB3ITGAVRETKDR | |
| SCHEMBL5495851 | 0.72 | KDM4A (0.43) | KDM4ANAAAPOLBGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |