Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGAV | P06756 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 5/20 | 0.34 |
| ▸ | MMP9 | P14780 | 5/20 | 0.34 |
| ▸ | MMP8 | P22894 | 5/20 | 0.34 |
| ▸ | MMP12 | P39900 | 5/20 | 0.34 |
| ▸ | MMP14 | P50281 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504521 | 1.00 | ITGB3 (0.39) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL5495006 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL5499706 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL5495822 | 0.74 | KDM4A (0.41) | ITGB3ITGAVRETKDRGAA | |
| SCHEMBL5496941 | 0.71 | CHRNB2 (0.46) | — | |
| SCHEMBL5492131 | 0.71 | CHRNB2 (0.46) | — | |
| SCHEMBL5501061 | 0.70 | ITGB3 (0.46) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| T-Butylacetic Acid SCHEMBL10533287 | 0.66 | MEN1 (0.40) | ITGB3ITGAVKMT2AMEN1NPC1 | |
| SCHEMBL6669034 | 0.64 | ITGAV (0.77) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL6669430 | 0.64 | ITGAV (0.82) | ITGB3ITGAVITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |