Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.32 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699799 | 1.00 | KEAP1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL550876 | 1.00 | KEAP1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL2699793 | 1.00 | KEAP1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL550877 | 1.00 | KEAP1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL549601 | 1.00 | KEAP1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL5631223 | 0.90 | HSD11B1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL4720720 | 0.90 | HSD11B1 (0.37) | KEAP1NFE2L2HSD11B1SCN9AATR | |
| SCHEMBL549672 | 0.85 | SCN9A (0.43) | HSD11B1SCN9A | |
| SCHEMBL550117 | 0.85 | SCN9A (0.43) | HSD11B1SCN9A | |
| SCHEMBL2699529 | 0.85 | SCN9A (0.43) | HSD11B1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |