Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 14/20 | 0.60 |
| ▸ | MAOB | P27338 | 14/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496132 | 0.87 | MAOA (0.54) | MAOAMAOBGSK3BPRKD3PRKCG | |
| SCHEMBL3856314 | 0.85 | MAOA (0.70) | MAOAMAOBGSK3BPRKD3PRKCG | |
| SCHEMBL5493085 | 0.83 | MAOA (0.72) | MAOAMAOBGSK3BPRKD3PRKCG | |
| SCHEMBL11543929 | 0.77 | NSD2 (0.62) | HSP90AA1HSP90AB1NSD2CASP6RAD52 | |
| SCHEMBL11547799 | 0.76 | POLB (0.37) | MAOAMAOBGSK3BHSP90AA1HSP90AB1 | |
| SCHEMBL14534511 | 0.75 | MAOA (0.78) | MAOAMAOBGSK3BPRKD3PRKCG | |
| SCHEMBL6157510 | 0.75 | ESR1 (0.63) | MAOAMAOBGSK3BPRKD3PRKCG | |
| SCHEMBL3856309 | 0.75 | MAOA (1.00) | MAOAMAOBGSK3BNSD2 | |
| SCHEMBL14443960 | 0.75 | MAOA (1.00) | MAOAMAOBGSK3BNSD2 | |
| SCHEMBL14443958 | 0.75 | MAOA (1.00) | MAOAMAOBGSK3BNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-B1 | Medicament comprising (-)-8-[(4-amino-1-méthylbutyl)amino]-5-(3,4-dichlorophénoxy)-6-méthoxy-4-méthylquinoline for the treatment of parasitic and opportunistic infections | UNIV MISSISSIPPI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-0907363-A4 | 8-AMINOQUINOLINES | UNIV MISSISSIPPI (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-0907363-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997036590-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1997-10-09 | — | — | WO | disclosed |