Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 9/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499448 | 0.85 | CYP1A2 (0.45) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5500442 | 0.84 | HTR1D (0.47) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5498985 | 0.82 | HTR2A (0.60) | KMT2AOPRM1OPRD1OPRK1SNCA | |
| SCHEMBL5498300 | 0.82 | MPO (0.53) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5501366 | 0.81 | HTR1A (0.45) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5499589 | 0.81 | OPRM1 (0.49) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5495196 | 0.80 | SNCA (0.58) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5499185 | 0.79 | SNCA (0.54) | CYP1A2HSD17B10HTR1AHTR1BHTR2C | |
| SCHEMBL5493877 | 0.79 | SNCA (0.54) | HTR6OPRM1OPRD1OPRK1SNCA | |
| SCHEMBL5498261 | 0.79 | SNCA (0.54) | CYP1A2HSD17B10HTR1AHTR1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751103-A1 | 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005090303-A1 | 4- (5- (AMINOMETHYL) -INDOLE-1-YLMETHYL) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | claimed |
| EP-1751103-A1 | 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005090303-A1 | 4- (5- (AMINOMETHYL) -INDOLE-1-YLMETHYL) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | disclosed |