Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24740182 | 0.84 | PDK2 (0.60) | PDK2PDK4POLBALDH1A1IDO1 | |
| SCHEMBL5500770 | 0.84 | PDK2 (0.60) | PDK2PDK4POLBALDH1A1IDO1 | |
| SCHEMBL30088920 | 0.79 | BRPF1 (0.53) | MAPTL3MBTL1ALDH1A1IDO1PGR | |
| SCHEMBL19054962 | 0.79 | BRPF1 (0.53) | MAPTL3MBTL1ALDH1A1IDO1PGR | |
| SCHEMBL260994 | 0.79 | BRPF1 (0.53) | MAPTL3MBTL1ALDH1A1IDO1PGR | |
| SCHEMBL5497405 | 0.72 | MAPT (0.48) | PDK2PDK4POLBMAPTL3MBTL1 | |
| SCHEMBL11535997 | 0.70 | PDK2 (0.47) | PDK2PDK4POLBMAPTALDH1A1 | |
| SCHEMBL15499981 | 0.70 | PDK2 (0.50) | PDK2PDK4POLBMAPTL3MBTL1 | |
| SCHEMBL3520823 | 0.69 | PDK2 (0.57) | PDK2PDK4POLBPGRGAA | |
| SCHEMBL29695374 | 0.69 | PDK2 (0.57) | PDK2PDK4POLBPGRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778222-A1 | PROGESTERONE RECEPTOR MODULATORS COMPRISING PYRROLE-OXINDOLE DERIVATIVES AND USES THEREOF | Wyeth (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023107-A1 | PROGESTERONE RECEPTOR MODULATORS COMPRISING PYRROLE-OXINDOLE DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |