SCHEMBL5496858

SCHEMBL5496858

O=C(O)NNC(=O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 18/20 0.44
DNMT1 P26358 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glyoxylate SCHEMBL6817449 0.91 KIF11 (0.39) KIF11DNMT1
SCHEMBL5495199 0.81 KIF11 (0.47) KIF11DNMT1
SCHEMBL10675433 0.81 KIF11 (0.54) KIF11DNMT1
SCHEMBL10503169 0.78 KIF11 (0.42) KIF11DNMT1
SCHEMBL11264441 0.78 KIF11 (0.48) KIF11DNMT1
SCHEMBL342181 0.77 KIF11 (0.50) KIF11DNMT1
SCHEMBL23700538 0.76 ESRRB (0.51) KIF11
SCHEMBL8349509 0.76 KIF11 (0.50) KIF11DNMT1
SCHEMBL16358480 0.74 KIF11 (0.54) KIF11DNMT1
SCHEMBL12347301 0.74 KIF11 (0.53) KIF11DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975374-B1 RADIOMETAL-BINDING PEPTIDE ANALOGUES IMMUNOMEDICS INC (US) 2007-12-05 EP disclosed
US-7045503-B1 Radiometal-binding peptide analogues IMMUNOMEDICS, INC. (US) 2006-05-16 US disclosed
EP-0836618-B1 RADIOMETAL-BINDING ANALOGUES OF LEUTENIZING HORMONE RELEASING HORMONE IMMUNOMEDICS INC (US) 2005-08-17 EP disclosed
US-RE37710-E1 IMAGING TUMOR IMMUNOMEDICS, INC. 2002-05-21 US disclosed