Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735630 | 0.85 | PDK1 (0.55) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL18138437 | 0.84 | TDP1 (0.53) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL5222523 | 0.84 | TSHR (0.59) | TDP1ALDH1A1TSHRHPGDMAPT | |
| SCHEMBL10662852 | 0.83 | GRM8 (0.52) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL2123108 | 0.82 | ALDH1A1 (0.55) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL29395878 | 0.82 | ALDH1A1 (0.55) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL9398085 | 0.82 | TDP1 (0.56) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL11426135 | 0.81 | TDP1 (0.59) | TDP1ALDH1A1MAPK1TSHRGPR35 | |
| SCHEMBL888171 | 0.81 | PDK1 (0.41) | TDP1ALDH1A1TSHRTP53GRM8 | |
| SCHEMBL5997466 | 0.81 | LMNA (0.55) | TDP1ALDH1A1MAPK1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1310487-B1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI SEIYAKU CO (JP) | 2007-01-03 | — | — | EP | disclosed |
| US-7074837-B2 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. | 2005-12-08 | — | — | US | disclosed |
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1310487-A1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-14 | — | — | EP | disclosed |
| EP-0829473-B1 | PROCESSES FOR PREPARING CYCLIC COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2002-08-07 | — | — | EP | disclosed |
| EP-1148047-A2 | Processes for preparing cyclic compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6218548-B1 | (TRIARYLMETHYL)AMINOSPIROPYRROLES | DAIICHI PAHARMACEUTICAL CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-6013806-A | ANTIBACTEIRAL | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-01-11 | — | — | US | disclosed |
| US-5856518-A | Production process of cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| EP-0829473-A1 | PROCESSES FOR PREPARING CYCLIC COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, CYP51A1, WEE1 | TDP1 2971/4885ALDH1A1 3657/4885MAPK1 934/4885 |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, WEE1, CYP51A1 | TDP1 3157/4885ALDH1A1 3827/4885MAPK1 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.