Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508843 | 0.88 | ALOX15 (0.50) | CYP19A1DRD2MAPTMAPK1TDP1 | |
| SCHEMBL5499276 | 0.75 | ESR2 (0.43) | CYP19A1DRD2ALOX15ALOX12 | |
| SCHEMBL21594807 | 0.72 | CYP19A1 (0.54) | HTR2CCYP19A1ADRA1ANPC1DRD2 | |
| SCHEMBL29042969 | 0.71 | HTR2C (0.60) | HTR2CCYP19A1ADRA1AKDM4EMEN1 | |
| SCHEMBL22667384 | 0.71 | HTR2C (0.70) | HTR2CADRA1AKDM4EMEN1NPC1 | |
| SCHEMBL7196340 | 0.71 | SNCA (0.46) | HTR2CCYP19A1KDM4EMEN1GAA | |
| SCHEMBL20138519 | 0.71 | HTR1A (0.41) | HTR2CCYP19A1MAPK1 | |
| SCHEMBL30943223 | 0.70 | TAAR1 (0.33) | CYP19A1KDM4EMEN1NPC1GAA | |
| SCHEMBL1268402 | 0.70 | PDE4A (0.62) | HTR2CKDM4EKMT2AMAPTMAPK1 | |
| SCHEMBL5234050 | 0.70 | HTR2C (0.51) | HTR2CCYP19A1ADRA1AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778656-A1 | BENZOXAZEPINE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023242-A1 | BENZOXAZEPINE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-02 | — | — | WO | disclosed |
| US-20060040917-A1 | Benzoxazepine derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040917-A1 | Benzoxazepine derivatives as selective estrogen receptor modulators | GPER1, ESR2, ESR1 | HTR2C 295/4885CYP19A1 8/4885ADRA1A 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.