Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991292 | 0.86 | L3MBTL1 (0.49) | HSP90AA1L3MBTL1ALOX15LMNATSHR | |
| SCHEMBL16463399 | 0.81 | L3MBTL1 (0.48) | HSP90AA1L3MBTL1ALOX15LMNATSHR | |
| SCHEMBL28291396 | 0.81 | HSP90AA1 (0.50) | HSP90AA1TSHRHPGDALDH1A1KDM4E | |
| SCHEMBL28292798 | 0.81 | L3MBTL1 (0.48) | HSP90AA1L3MBTL1ALOX15LMNATSHR | |
| SCHEMBL27991513 | 0.79 | L3MBTL1 (0.48) | L3MBTL1ALOX15LMNATSHRTP53 | |
| SCHEMBL182953 | 0.78 | ALDH1A1 (0.54) | L3MBTL1ALOX15LMNATSHRTP53 | |
| SCHEMBL28291406 | 0.77 | HPGD (0.42) | HSP90AA1L3MBTL1ALOX15LMNATSHR | |
| SCHEMBL28271013 | 0.77 | L3MBTL1 (0.66) | HSP90AA1L3MBTL1ALOX15LMNATSHR | |
| SCHEMBL744542 | 0.75 | POLB (0.64) | L3MBTL1ALOX15LMNATSHRKMT2A | |
| SCHEMBL1298702 | 0.73 | POLB (0.54) | L3MBTL1ALOX15LMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761504-A2 | FACTOR VIIA INHIBITOR | PHARMACYCLICS, INC. (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005118554-A2 | FACTOR VIIA INHIBITOR | PHARMACYCLICS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |