Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499900 | 0.99 | GAA (0.39) | TMEM97SIGMAR1HTTGAALPAR1 | |
| SCHEMBL5499890 | 0.86 | GAA (0.36) | GAALPAR1ALDH1A1 | |
| SCHEMBL5158077 | 0.78 | ALDH1A1 (0.48) | GAAKMT2AALDH1A1 | |
| SCHEMBL5494080 | 0.74 | TACR2 (0.55) | — | |
| SCHEMBL5492268 | 0.73 | TACR2 (0.57) | ALDH1A1 | |
| SCHEMBL5494652 | 0.70 | TACR2 (0.53) | ALDH1A1 | |
| SCHEMBL6543815 | 0.69 | EPHX2 (0.38) | TMEM97SIGMAR1GAA | |
| SCHEMBL5491193 | 0.69 | TACR2 (0.55) | ALDH1A1 | |
| SCHEMBL6377833 | 0.68 | SIGMAR1 (0.47) | SIGMAR1GAAALDH1A1 | |
| SCHEMBL6377764 | 0.68 | CYP3A4 (0.48) | GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |