Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498618 | 0.86 | TMEM97 (0.39) | GAAALDH1A1LPAR1 | |
| SCHEMBL5499900 | 0.85 | GAA (0.39) | GAAALDH1A1USP2HPGDLPAR1 | |
| SCHEMBL5494954 | 0.81 | LMNA (0.45) | GAAHPGDLMNATSHR | |
| SCHEMBL5495837 | 0.76 | POLB (0.41) | GAAALDH1A1HPGDLMNACYP2C19 | |
| SCHEMBL5501523 | 0.74 | POLB (0.41) | GAAALDH1A1HPGDLMNATSHR | |
| SCHEMBL5158077 | 0.72 | ALDH1A1 (0.48) | GAAALDH1A1USP2HPGDTSHR | |
| SCHEMBL5489864 | 0.72 | CHRNA1 (0.48) | — | |
| SCHEMBL5493574 | 0.72 | CHRNA1 (0.47) | ALDH1A1USP2HPGD | |
| SCHEMBL8089921 | 0.71 | MMP8 (0.48) | SPHK1EPHX2EPHX1CYP3A4CYP2C19 | |
| SCHEMBL8083610 | 0.71 | MMP8 (0.54) | GAASPHK1HPGDEPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753782-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123770-A1 | MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |