SCHEMBL5498680

SCHEMBL5498680

Clc1ccc(-c2ncncn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
RPA1 P27694 1/20 0.43
HRH4 Q9H3N8 1/20 0.42
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
LMNA P02545 1/20 0.40
CYP2A6 P11509 1/20 0.40
CYP1A2 P05177 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
NOTUM Q6P988 4/20 0.39
METAP2 P50579 1/20 0.39
GCGR P47871 1/20 0.39
MAPK10 P53779 1/20 0.39
MAPK14 Q16539 1/20 0.39
TSHR P16473 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
CYP19A1 P11511 1/20 0.37
NR1H4 Q96RI1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1421973 0.87 NPC1 (0.40) NPC1RAB9AMAPTMEN1KMT2A
SCHEMBL29197367 0.83 CYP1A2 (0.52) NPC1RAB9ALMNACYP2A6CYP1A2
SCHEMBL13364856 0.77 CYP19A1 (0.53) NPC1RAB9ARPA1MAPTMEN1
SCHEMBL582179 0.75 NPC1 (0.58) NPC1RAB9AMAPTCYP1A2SMN1; SMN2
SCHEMBL195814 0.75 MEN1 (0.60) NPC1RAB9AMAPTMEN1KMT2A
SCHEMBL28489616 0.75 METAP2 (0.39) NPC1RAB9AHRH4MAPTMEN1
SCHEMBL6565672 0.75 MEN1 (0.60) NPC1RAB9AMAPTMEN1KMT2A
SCHEMBL28434393 0.75 TSHR (0.40) MEN1KMT2ACYP1A2SMN1; SMN2TSHR
SCHEMBL3119508 0.75 NPC1 (0.41) NPC1RAB9AMAPTMEN1KMT2A
SCHEMBL6048308 0.75 NPC1 (0.52) NPC1RAB9AMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119074563-A Dental curable composition containing ultraviolet absorber 株式会社松风 2024-12-06 CN disclosed
CN-113402666-B Dental photocurable composition excellent in color tone selectivity 株式会社松风 2024-11-15 CN disclosed
CN-113402665-B Dental photocurable composition comprising a highly soluble photoacid generator 株式会社松风 2024-11-15 CN disclosed
CN-117586179-A GPR183 antagonist and synthetic method and application thereof 中国人民解放军海军特色医学中心 2024-02-23 CN disclosed
CN-117597403-A Composition and method for protecting a coating from harmful effects of exposure to UV-C light 塞特工业公司 2024-02-23 CN disclosed
CN-116783246-A Compositions and methods for protecting organic polymeric materials from discoloration due to exposure to UV-C light 塞特工业公司 2023-09-19 CN disclosed
CN-115551915-A Polymerizable unsaturated group-containing alkali-soluble resin and method for producing same, and photosensitive resin composition and cured product thereof 日铁化学材料株式会社 2022-12-30 CN disclosed
CN-102181051-B Hyperbranched polyarylether containing triazine structure and preparation method thereof UNIV DALIAN TECH 2013-04-10 CN disclosed
US-20130059869-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS HYDRA BIOSCIENCES, INC. 2013-03-07 US disclosed
CN-102181051-A Hyperbranched polyarylether containing triazine structure and preparation method thereof UNIV DALIAN TECH 2011-09-14 CN disclosed
EP-0389429-A2 Azo compounds containing hindered amine moieties with low basicity CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389434-A1 Bis(1-hydrocarbyloxy-2,2,6,6-tetramethylpiperidin-4-yl)-amine Derivatives and Stabilized compositions CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389423-A1 Peroxide compounds containing hindered amine moieties with low basicity CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389427-A2 Compounds containing both uv-absorber and 1-hydrocarbyloxy hindered amine moieties and stabilized compositions CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389422-A2 Stabilizers derived from N-hydroxy hindered amines by Michael addition reactions CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389430-A1 N-hydrocarbyloxy hindered amine light stabilizers substituted with phosphorus moieties CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389419-A1 Non-migrating 1-hydrocarbyloxy hindered amine compounds as polymer stabilizers CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389420-A1 Ethylenically unsaturated compounds containing 1-hydrocarbyloxy-2,2,6,6-tetramethylpiperidine moieties, and polymers, copolymers and stabilized compositions CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389421-A1 Poly(1-hydrocarbyloxy-2,2,6,6-tetraalkylpiperidine) light stabilizers CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389431-A2 N-Hydrocarbyloxy derivatives of hindered amine-substituted s-triazines CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130059869-A1 METHODS AND COMPOSITIONS FOR TREATING DISORDERS TRPA1, TRPV1, TRPV3 NPC1 73/4885RAB9A 2306/4885RPA1 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.