Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | TLR4 | O00206 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860577 | 0.79 | NSD3 (0.32) | NSD3TP53MEN1ALDH1A1MAPT | |
| SCHEMBL3863729 | 0.76 | MEN1 (0.31) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL4735509 | 0.73 | NSD3 (0.44) | NSD3HTR2CHTR2AHTR2BCHRNB2 | |
| Hydrochloric Acid SCHEMBL3868559 | 0.72 | NSD3 (0.43) | NSD3KMT2AHTR2CHTR2AHTR2B | |
| SCHEMBL3858769 | 0.71 | PLAT (0.41) | ALDH1A1HTR2CHTR2AHTR2B | |
| SCHEMBL6160296 | 0.62 | MAPT (0.36) | NSD3TP53MEN1ALDH1A1MAPT | |
| SCHEMBL9965946 | 0.62 | GABRA1 (0.37) | NSD3MEN1ALDH1A1MAPTPKM | |
| SCHEMBL7206524 | 0.61 | TP53 (0.35) | NSD3TP53MEN1ALDH1A1MAPT | |
| SCHEMBL6860901 | 0.60 | ALDH1A1 (0.38) | NSD3TP53MEN1ALDH1A1MAPT | |
| SCHEMBL3600197 | 0.60 | PRKCG (0.36) | NSD3TP53TLR8TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742934-A2 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | AstraZeneca AB (SE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005101989-A2 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | WO | disclosed |