Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | SCN4A | P35499 | 5/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652751 | 0.80 | TAAR1 (0.41) | TAAR1ADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL13676858 | 0.78 | TACR1 (0.46) | TAAR1ADRA2ALMNAKDM4EALDH1A1 | |
| SCHEMBL3092744 | 0.78 | TAAR1 (0.41) | TAAR1ADRA2ALMNAKDM4EALDH1A1 | |
| SCHEMBL2178101 | 0.78 | DPP4 (0.44) | TAAR1SCN4AADRA2AADRA2CLMNA | |
| SCHEMBL27610659 | 0.78 | SRC (0.41) | TAAR1SCN4AADRA2AADRA2CLMNA | |
| SCHEMBL28453256 | 0.75 | HTR2A (0.43) | TAAR1ADRA2ALMNAKDM4EALDH1A1 | |
| SCHEMBL5506617 | 0.75 | LMNA (0.42) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL19798765 | 0.75 | LMNA (0.44) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL28507818 | 0.75 | NPSR1 (0.39) | TAAR1ADRA2ALMNAKDM4EALDH1A1 | |
| SCHEMBL5179528 | 0.75 | DPP4 (0.41) | TAAR1SCN4AADRA2AADRA2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153016-A | Preparation method of pimavanserin | BEIJING NUOKANGDA PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-12-16 | — | — | CN | claimed |
| EP-1794126-A1 | SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS | Acadia Pharmaceuticals Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037043-A1 | SYNTHESIS OF N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N'-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND CRYSTALLINE FORMS | ACADIA PHARMACEUTICALS INC. (US) | 2006-04-06 | — | — | WO | disclosed |