Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067246 | 0.90 | DPP4 (0.42) | DPP4EPHX2 | |
| SCHEMBL17291825 | 0.70 | HTR1A (0.39) | HTR1AKMT2A | |
| SCHEMBL5499199 | 0.68 | GAA (0.44) | HTR1AKMT2A | |
| SCHEMBL10667378 | 0.67 | MAPT (0.34) | EPHX2 | |
| SCHEMBL1848674 | 0.67 | TSHR (0.36) | HTR1AKMT2A | |
| SCHEMBL1848675 | 0.67 | TSHR (0.36) | HTR1AKMT2A | |
| SCHEMBL21316453 | 0.67 | ANPEP (0.42) | HTR1AKMT2A | |
| SCHEMBL6390292 | 0.67 | ANPEP (0.42) | HTR1AKMT2A | |
| SCHEMBL6390289 | 0.67 | ANPEP (0.42) | HTR1AKMT2A | |
| SCHEMBL22744300 | 0.65 | EPHX2 (0.36) | KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737854-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100351-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |