Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.50 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241890 | 0.83 | BRAF (0.67) | BRAF | |
| Hydrochloric Acid SCHEMBL9228583 | 0.78 | RXFP1 (0.58) | GAAPTGS1RXFP1ALDH1A1 | |
| SCHEMBL9220315 | 0.77 | RXFP1 (0.57) | GAAPTGS1RXFP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9229016 | 0.77 | RXFP1 (0.56) | GAAPTGS1RXFP1ALDH1A1BRAF | |
| SCHEMBL31606898 | 0.75 | ALDH1A1 (0.62) | GAAPTGS1RXFP1ALDH1A1ALOX15 | |
| SCHEMBL28633823 | 0.75 | PTGS1 (0.72) | GAAPTGS1RXFP1ALDH1A1LMNA | |
| SCHEMBL11868617 | 0.75 | PTGS1 (0.72) | GAAPTGS1RXFP1ALDH1A1LMNA | |
| SCHEMBL30136206 | 0.75 | PTGS1 (0.72) | GAAPTGS1RXFP1ALDH1A1LMNA | |
| SCHEMBL3941624 | 0.75 | KMT2A (0.67) | GAAPTGS1RXFP1ALDH1A1LMNA | |
| SCHEMBL9226881 | 0.74 | RXFP1 (0.53) | GAAPTGS1RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858521-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS | IRM, LLC (BM) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006101783-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-09-28 | — | — | WO | disclosed |