Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013273 | 1.00 | ALDH1A1 (0.59) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL2007611 | 0.98 | GAA (0.59) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL12570903 | 0.95 | MMP2 (0.57) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL2009051 | 0.94 | MMP2 (0.59) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL5435010 | 0.93 | GAA (0.60) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL9780583 | 0.91 | ALDH1A1 (0.67) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL1348420 | 0.86 | ALDH1A1 (0.64) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL23683085 | 0.83 | GAA (0.61) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL7613900 | 0.83 | TBXA2R (0.62) | ALDH1A1GAAPKMMEN1KMT2A | |
| SCHEMBL10078758 | 0.83 | ALDH1A1 (0.75) | ALDH1A1GAAPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | disclosed |