Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503074 | 0.87 | DPP4 (0.32) | DPP4DPP8DPP9POLBMEN1 | |
| SCHEMBL5504616 | 0.87 | LMNA (0.44) | DPP4DPP8DPP9POLBMEN1 | |
| SCHEMBL5499906 | 0.87 | LMNA (0.44) | DPP4DPP8DPP9POLBMEN1 | |
| SCHEMBL5503253 | 0.85 | DPP4 (0.31) | DPP4DPP8DPP9 | |
| SCHEMBL5504490 | 0.84 | POLB (0.35) | DPP4DPP8DPP9HTR2CHTR2A | |
| SCHEMBL5503369 | 0.83 | LMNA (0.43) | DPP4DPP8DPP9POLBMEN1 | |
| SCHEMBL5504613 | 0.83 | HTR2C (0.39) | DPP4DPP8DPP9HTR2CHTR2A | |
| SCHEMBL5504207 | 0.82 | MEN1 (0.33) | DPP4DPP8DPP9HTR2CHTR2A | |
| SCHEMBL5503146 | 0.81 | HTR2C (0.38) | HTR2CHTR2AHTR2BP2RX7 | |
| SCHEMBL5499740 | 0.80 | DPP4 (0.36) | DPP4DPP8DPP9POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |