Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504613 | 0.84 | HTR2C (0.39) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5499906 | 0.84 | LMNA (0.44) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5504616 | 0.84 | LMNA (0.44) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5499746 | 0.84 | DPP4 (0.36) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5508747 | 0.84 | CHRNB2 (0.40) | HTR2CHCRTR1HCRTR2HTR2AHTR2B | |
| SCHEMBL5503369 | 0.81 | LMNA (0.43) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5504207 | 0.79 | MEN1 (0.33) | POLBMEN1KMT2ADPP4DPP8 | |
| SCHEMBL5504232 | 0.79 | CTSS (0.36) | DPP4DPP8DPP9PDCD1LG2CD274 | |
| SCHEMBL5505692 | 0.79 | HSD11B1 (0.40) | HCRTR1HCRTR2ALDH1A1SMN1; SMN2MGLL | |
| SCHEMBL5506971 | 0.79 | CNR2 (0.32) | PDCD1LG2CD274CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |