Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503253 | 0.89 | DPP4 (0.31) | DPP4DPP8DPP9TACR1 | |
| SCHEMBL5504207 | 0.89 | MEN1 (0.33) | DPP4DPP8DPP9PDCD1LG2CD274 | |
| SCHEMBL5499746 | 0.87 | DPP4 (0.36) | DPP4DPP8DPP9PDCD1LG2CD274 | |
| SCHEMBL5499740 | 0.87 | DPP4 (0.36) | DPP4DPP8DPP9PDCD1LG2CD274 | |
| SCHEMBL5502855 | 0.84 | F10 (0.33) | DPP4DPP8DPP9F10 | |
| SCHEMBL5503355 | 0.84 | MEN1 (0.34) | DPP4DPP8DPP9MEN1KMT2A | |
| SCHEMBL5503476 | 0.81 | PDCD1LG2 (0.32) | PDCD1LG2CD274 | |
| SCHEMBL5506971 | 0.81 | CNR2 (0.32) | PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5505492 | 0.81 | PDCD1LG2 (0.31) | PDCD1LG2CD274 | |
| SCHEMBL5499906 | 0.80 | LMNA (0.44) | DPP4DPP8DPP9MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |