SCHEMBL5499762

SCHEMBL5499762

O=C1CCC(N2CCCC2=O)CC1Cc1ccc(Cl)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 15/20 0.42
EPHX2 P34913 1/20 0.40
KMT2A Q03164 1/20 0.40
DPP4 P27487 1/20 0.40
DPP8 Q6V1X1 1/20 0.40
DPP9 Q86TI2 1/20 0.40
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
F10 P00742 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5500031 0.81 P2RX7 (0.44) P2RX7EPHX2KMT2ADPP4DPP8
SCHEMBL5503988 0.81 P2RX7 (0.45) P2RX7EPHX2DPP4DPP8DPP9
SCHEMBL5505679 0.80 P2RX7 (0.44) P2RX7EPHX2KMT2ADPP4DPP8
SCHEMBL5505968 0.79 P2RX7 (0.41) P2RX7KMT2ADPP4DPP8DPP9
SCHEMBL5506138 0.78 P2RX7 (0.46) P2RX7KMT2ADPP4DPP8DPP9
SCHEMBL5503442 0.77 P2RX7 (0.41) P2RX7KMT2ALMNAPOLBSMN1; SMN2
SCHEMBL3945116 0.75 SIGMAR1 (0.36) F10
SCHEMBL5506343 0.75 P2RX7 (0.46) P2RX7
SCHEMBL5500515 0.74 P2RX7 (0.42) P2RX7KMT2ALMNAPOLBSMN1; SMN2
SCHEMBL5501290 0.74 KMT2A (0.43) P2RX7KMT2ALMNAPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807072-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-07-18 EP claimed
WO-2006049952-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2006-05-11 WO claimed
EP-1807072-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-07-18 EP disclosed
WO-2006049952-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2006-05-11 WO disclosed