Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500515 | 0.85 | P2RX7 (0.42) | P2RX7KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL5505535 | 0.82 | P2RX7 (0.41) | P2RX7KMT2ASIGMAR1 | |
| SCHEMBL5499762 | 0.77 | P2RX7 (0.42) | P2RX7KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL5501290 | 0.76 | KMT2A (0.43) | P2RX7KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL5505772 | 0.75 | KMT2A (0.35) | P2RX7KMT2ALMNASMN1; SMN2 | |
| SCHEMBL5500672 | 0.75 | CYP2A13 (0.39) | P2RX7KMT2ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL5505968 | 0.71 | P2RX7 (0.41) | P2RX7KMT2A | |
| SCHEMBL5500083 | 0.71 | HCRTR1 (0.33) | P2RX7 | |
| SCHEMBL5500031 | 0.70 | P2RX7 (0.44) | P2RX7KMT2A | |
| Hydrochloric Acid SCHEMBL5505760 | 0.70 | HCRTR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |