Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29602380 | 1.00 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL31515802 | 0.98 | HTR2A (0.41) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Bromide SCHEMBL3381114 | 0.95 | HTR2A (0.45) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Fluoride Ion SCHEMBL1130988 | 0.95 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Iodide SCHEMBL3385271 | 0.95 | HTR2A (0.40) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL7113536 | 0.89 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL9158981 | 0.86 | SIGMAR1 (0.35) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL29480029 | 0.86 | HTR2A (0.38) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Bicarbonate SCHEMBL31537215 | 0.86 | HTR2A (0.34) | HTR2AHTR6KDM4ECYP2D6BRD4 | |
| Hydrochloric Acid SCHEMBL18663160 | 0.85 | RET (0.39) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401977-A | Transition metal compound and catalyst composition comprising the same | 株式会社LG化学 | 2022-04-26 | — | — | CN | disclosed |
| EP-2310124-B1 | HALF-METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2014-11-26 | — | — | EP | disclosed |
| US-8242221-B2 | Half-metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-08-14 | — | — | US | disclosed |
| US-20120108764-A1 | HALF-METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-05-03 | — | — | US | disclosed |
| US-8110640-B2 | Half-metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-02-07 | — | — | US | disclosed |
| EP-2310124-A1 | HALF-METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | Chevron Phillips Chemical Company LP (US) | 2011-04-20 | — | — | EP | disclosed |
| US-20110065874-A1 | HALF-METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2011-03-17 | — | — | US | disclosed |
| US-7884165-B2 | polymerization coordination catalysts comprising metal complex of zirconium, titanium, or hafnium having (substituted) cyclopentadienyl, indenyl, and/or fluorenyl groups; and organoaluminum halide, hydride and/or hydroxide; fluorided alumina-silica catalyst support | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2011-02-08 | — | — | US | disclosed |
| US-7709586-B2 | Olefin polymerization catalyst and olefin polymerization process using the same | DAELIM INDUSTRIAL CO., LTD. (KR) | 2010-05-04 | — | — | US | disclosed |
| WO-2010008515-A1 | HALF-METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2010-01-21 | — | — | WO | disclosed |
| US-5492974-A | Process for preparing polymer bound metallocenes | PHILLIPS PETROLEUM COMPANY (US) | 1996-02-20 | — | — | US | disclosed |
| EP-0690076-A1 | Polymer bound ligands, polymer bound metallocenes, catalyst systems, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5474962-A | Powder catalyst composition and process for polymerizing olefins with the use thereof | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1995-12-12 | — | — | US | disclosed |
| US-5473020-A | Polymer bound ligands, polymer bound metallocenes, catalyst systems, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-12-05 | — | — | US | disclosed |
| US-5461127-A | Comprising group 4 metal, cyclic hydrocarbon, ligands, Lewis base; addition polymerization | IDEMITSU KOSAN CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0591756-A2 | Polymerization catalysts and process for producing polymers | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-04-13 | — | — | EP | disclosed |
| EP-0589638-A2 | Powder catalyst composition and process for polymerizing olefins with the use thereof | MITSUBISHI CHEMICAL CORPORATION (JP) | 1994-03-30 | — | — | EP | disclosed |
| EP-0576213-A2 | Process for polymerizing olefins | MITSUBISHI CHEMICAL CORPORATION (JP) | 1993-12-29 | — | — | EP | disclosed |
| US-5270407-A | Polysiloxane to prevent adhesion of copolymer to support | EXXON CHEMICAL PATENTS INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0535230-A1 | PROCESS FOR PRODUCING ETHYLENIC COPOLYMER | EXXON CHEMICAL PATENTS INC. (US) | 1993-04-07 | — | — | EP | disclosed |