Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168421 | 0.75 | MAPT (0.38) | RAPGEF4 | |
| SCHEMBL3410831 | 0.72 | ALDH1A1 (0.37) | RAPGEF4 | |
| SCHEMBL5500392 | 0.70 | RAPGEF4 (0.31) | RAPGEF4 | |
| SCHEMBL225914 | 0.69 | RAPGEF4 (0.38) | RAPGEF4PDK2 | |
| SCHEMBL2944478 | 0.68 | ESR2 (0.42) | — | |
| SCHEMBL20553843 | 0.68 | RAPGEF4 (0.34) | RAPGEF4PDK2 | |
| SCHEMBL162868 | 0.68 | — | — | |
| SCHEMBL17514794 | 0.67 | — | — | |
| SCHEMBL317299 | 0.66 | RAPGEF4 (0.50) | RAPGEF4 | |
| SCHEMBL28713658 | 0.65 | RAPGEF4 (0.43) | RAPGEF4PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817294-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006019975-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |