SCHEMBL6168421

SCHEMBL6168421

Cc1[c]cc(C)c(-c2ccc(C)cc2C)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.38
GAA P10253 1/20 0.38
TDP1 Q9NUW8 2/20 0.35
TP53 P04637 2/20 0.35
LMNA P02545 2/20 0.33
ALPL P05186 2/20 0.33
CA9 Q16790 1/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
ELANE P08246 1/20 0.31
ALDH1A1 P00352 3/20 0.31
HPGD P15428 2/20 0.31
KDM4E B2RXH2 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CYP1A2 P05177 2/20 0.31
CYP2A6 P11509 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3410831 0.86 ALDH1A1 (0.37) MAPTGAATDP1TP53LMNA
SCHEMBL31547677 0.78 TDP1 (0.52) MAPTGAATDP1TP53LMNA
SCHEMBL3043421 0.78 TDP1 (0.52) MAPTGAATDP1TP53LMNA
SCHEMBL5500396 0.75 RAPGEF4 (0.31) RAPGEF4
SCHEMBL20554010 0.73 MAPT (0.39) MAPTGAATDP1TP53LMNA
SCHEMBL20076409 0.73 LMNA (0.50) MAPTGAATDP1TP53LMNA
SCHEMBL29038580 0.73 MAPT (0.48) MAPTGAATDP1TP53LMNA
SCHEMBL4817133 0.71 MAPT (0.40) MAPTGAATDP1TP53LMNA
SCHEMBL2944478 0.69 ESR2 (0.42) MAPTTDP1LMNARAB9AMEN1
SCHEMBL1980000 0.69 PLA2G7 (0.51) MAPTGAATP53LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1373249-B1 IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, AND THEIR USE AS ANTIINFLAMATORY AGENT AVENTIS PHARMA GMBH (DE) 2005-04-20 EP disclosed
EP-1373249-A1 IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, AND THEIR USE AS ANTINFLAMATORY AGENT Aventis Pharma Deutschland GmbH (DE) 2004-01-02 EP disclosed
WO-2002072573-A1 IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, AND THEIR USE AS ANTINFLAMATORY AGENT. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-09-19 WO disclosed