SCHEMBL5500465

SCHEMBL5500465

NC[C@@H]1CN(c2cc3c(c(F)c2CCF)NC(=O)C3)C(=O)O1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.35
GRM2 Q14416 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5502203 0.88 F10 (0.34) F10GRM2
SCHEMBL5499076 0.85 GRM2 (0.37) F10GRM2
SCHEMBL5506392 0.83 GRM2 (0.36) F10GRM2
SCHEMBL5502896 0.78 F10 (0.36) F10GRM2
SCHEMBL5498389 0.76 DRD2 (0.33)
SCHEMBL5501644 0.71 F10 (0.35) F10GRM2
SCHEMBL5499874 0.71 F10 (0.39) F10GRM2
SCHEMBL5502470 0.70 F10 (0.37) F10
SCHEMBL5502999 0.70 F10 (0.37) F10
SCHEMBL5499712 0.70 DPP4 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869030-A1 7-FLUORO-1,3-DIHYDRO-INDOL-2-ONE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS Pharmacia & Upjohn Company LLC (US) 2007-12-26 EP disclosed
EP-1781643-A1 OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS Pharmacia & Upjohn Company LLC (US) 2007-05-09 EP disclosed
WO-2006106427-A1 7-FLUORO-1,3-DIHYDRO-INDOL-2-ONE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-10-12 WO disclosed
WO-2006016220-A1 OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-02-16 WO disclosed