Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5499707 | 0.99 | ATM (0.40) | ATMESR1ATRHRH3LSS | |
| SCHEMBL5503492 | 0.96 | ESR1 (0.43) | ATMESR1ATRHRH3LSS | |
| Hydrochloric Acid SCHEMBL5500694 | 0.95 | ESR1 (0.42) | ATMESR1ATRHRH3LSS | |
| SCHEMBL5503554 | 0.91 | PARP1 (0.34) | ATMESR1ATRHRH3UTS2R | |
| SCHEMBL5500808 | 0.86 | ESR1 (0.37) | ESR1HRH3PIK3CAPARP1 | |
| SCHEMBL5500801 | 0.82 | CHEK2 (0.37) | — | |
| SCHEMBL5504232 | 0.82 | CTSS (0.36) | — | |
| Hydrochloric Acid SCHEMBL5500756 | 0.82 | CHEK2 (0.36) | — | |
| SCHEMBL5499827 | 0.81 | P2RX7 (0.34) | — | |
| SCHEMBL5506180 | 0.80 | AAK1 (0.34) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |