Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 2/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502995 | 0.89 | NPY5R (0.38) | NPY5RP2RX7HCRTR1HCRTR2CCR5 | |
| SCHEMBL5503929 | 0.88 | CTSS (0.36) | NPY5RDPP4DPP8DPP9P2RX7 | |
| SCHEMBL5499959 | 0.86 | CYP11B1 (0.38) | NPY5RP2RX7HCRTR1HCRTR2 | |
| SCHEMBL5501184 | 0.86 | NPY5R (0.35) | NPY5RHSD11B1DPP4DPP8DPP9 | |
| SCHEMBL5500031 | 0.82 | P2RX7 (0.44) | DPP4DPP8DPP9P2RX7F10 | |
| SCHEMBL5506180 | 0.81 | AAK1 (0.34) | NPY5RHSD11B1DPP4DPP8DPP9 | |
| SCHEMBL5500067 | 0.81 | KMT2A (0.36) | DPP4DPP8DPP9P2RX7F10 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.80 | AAK1 (0.33) | NPY5RHSD11B1DPP4DPP8DPP9 | |
| SCHEMBL5506323 | 0.78 | DPP4 (0.40) | NPY5RDPP4DPP8DPP9P2RX7 | |
| SCHEMBL5504727 | 0.77 | NPY5R (0.37) | NPY5RHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |