Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500031 | 0.86 | P2RX7 (0.44) | DPP4DPP8DPP9F10P2RX7 | |
| SCHEMBL5501783 | 0.78 | LMNA (0.43) | DPP4DPP8DPP9P2RX7 | |
| SCHEMBL5500067 | 0.78 | KMT2A (0.36) | DPP4DPP8DPP9F10P2RX7 | |
| SCHEMBL5500612 | 0.78 | NPY5R (0.36) | DPP4DPP8DPP9F10P2RX7 | |
| SCHEMBL5504560 | 0.76 | BTK (0.38) | DPP4DPP8DPP9P2RX7 | |
| SCHEMBL5503929 | 0.76 | CTSS (0.36) | DPP4DPP8DPP9P2RX7NPY5R | |
| SCHEMBL5502995 | 0.75 | NPY5R (0.38) | P2RX7NPY5R | |
| SCHEMBL5505679 | 0.75 | P2RX7 (0.44) | DPP4DPP8DPP9F10P2RX7 | |
| SCHEMBL5502942 | 0.74 | LMNA (0.38) | DPP4DPP8DPP9P2RX7 | |
| SCHEMBL5503441 | 0.72 | TACR1 (0.36) | F10NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |