Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.35 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.35 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.35 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502881 | 0.91 | TP53BP1 (0.40) | TP53BP1L3MBTL3L3MBTL1LMNAP2RX7 | |
| SCHEMBL5500968 | 0.85 | AR (0.42) | TP53BP1L3MBTL3L3MBTL1CDK4CCND1 | |
| SCHEMBL5500736 | 0.81 | KMT2A (0.35) | L3MBTL1P2RX7 | |
| SCHEMBL5506343 | 0.81 | P2RX7 (0.46) | ALDH1A1P2RX7 | |
| SCHEMBL5503988 | 0.80 | P2RX7 (0.45) | LMNAP2RX7 | |
| SCHEMBL4069500 | 0.80 | HPGD (0.42) | L3MBTL3L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5500156 | 0.80 | HPGD (0.42) | L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL5504232 | 0.79 | CTSS (0.36) | P2RX7 | |
| SCHEMBL5506132 | 0.79 | SLC6A2 (0.36) | P2RX7 | |
| SCHEMBL5499828 | 0.79 | DPP4 (0.38) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |