Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499828 | 0.97 | DPP4 (0.38) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL5506343 | 0.87 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL5503988 | 0.85 | P2RX7 (0.45) | P2RX7DPP4DPP8DPP9SMN1; SMN2 | |
| SCHEMBL5502881 | 0.84 | TP53BP1 (0.40) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL5506132 | 0.84 | SLC6A2 (0.36) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL4069187 | 0.84 | CCRL2 (0.33) | P2RX7 | |
| SCHEMBL5504232 | 0.84 | CTSS (0.36) | P2RX7DPP4DPP8DPP9PDCD1LG2 | |
| SCHEMBL5503413 | 0.83 | DPP4 (0.36) | P2RX7DPP4DPP8DPP9L3MBTL1 | |
| SCHEMBL5499827 | 0.83 | P2RX7 (0.34) | P2RX7DPP4DPP8DPP9F10 | |
| SCHEMBL5506180 | 0.82 | AAK1 (0.34) | P2RX7DPP4DPP8DPP9PDCD1LG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |