Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 10/20 | 0.67 |
| ▸ | RAB9A | P51151 | 10/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061754 | 0.93 | ALOX5 (0.77) | ALOX5NPC1RAB9AMAPTKMT2A | |
| SCHEMBL2633343 | 0.93 | ALOX5 (0.77) | ALOX5NPC1RAB9AMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9423776 | 0.92 | ALOX5 (0.75) | ALOX5NPC1RAB9AMAPTKMT2A | |
| SCHEMBL1881120 | 0.89 | KMT2A (0.71) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL1979717 | 0.89 | KMT2A (0.71) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL6816201 | 0.88 | RAB9A (0.83) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL11462217 | 0.88 | RAB9A (0.83) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL23898948 | 0.82 | KMT2A (0.83) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL9134339 | 0.82 | KMT2A (0.83) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL8020422 | 0.82 | ALDH1A1 (0.69) | NPC1RAB9AMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768709-A1 | A METHOD OF DIAGNOSING PRODROMAL FORMS OF DISEASES ASSOCIATED WITH AMYLOID DEPOSITION | University of Pittsburgh (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006014382-A1 | A METHOD OF DIAGNOSING PRODROMAL FORMS OF DISEASES ASSOCIATED WITH AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH (US) | 2006-02-09 | — | — | WO | disclosed |
| EP-1611115-A1 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES | University of Pittsburgh (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004083195-A1 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES | UNIVERSITY OF PITTSBURGH (US) | 2004-09-30 | — | — | WO | disclosed |