Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506180 | 0.77 | AAK1 (0.34) | HSD11B1NPY5RP2RX7DPP4DPP8 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.76 | AAK1 (0.33) | HSD11B1NPY5RP2RX7DPP4DPP8 | |
| SCHEMBL5500612 | 0.72 | NPY5R (0.36) | HSD11B1USP7NPY5RP2RX7DPP4 | |
| SCHEMBL5500083 | 0.70 | HCRTR1 (0.33) | HSD11B1USP7P2RX7GPR142CDC7 | |
| Hydrochloric Acid SCHEMBL5505760 | 0.70 | HCRTR1 (0.33) | HSD11B1USP7GPR142 | |
| SCHEMBL5501423 | 0.69 | HTR6 (0.34) | HSD11B1NPY5RDPP4DPP8DPP9 | |
| SCHEMBL5500749 | 0.68 | MEN1 (0.39) | HSD11B1DPP4DPP8DPP9CTSS | |
| Hydrochloric Acid SCHEMBL5506619 | 0.68 | HTR6 (0.33) | HSD11B1NPY5RDPP4DPP8DPP9 | |
| SCHEMBL5499827 | 0.68 | P2RX7 (0.34) | NPY5RP2RX7DPP4DPP8DPP9 | |
| SCHEMBL5504552 | 0.68 | NPY5R (0.34) | NPY5RP2RX7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |