Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15319916 | 0.80 | ADRA2A (0.39) | DRD1 | |
| SCHEMBL3715028 | 0.79 | GID4 (0.41) | DRD1DRD2 | |
| SCHEMBL1660824 | 0.72 | DRD2 (0.50) | DRD2HTR1AESR1ESR2 | |
| SCHEMBL19661160 | 0.72 | DRD2 (0.50) | DRD2HTR1AESR1ESR2 | |
| SCHEMBL1598610 | 0.70 | DRD2 (0.45) | DRD1DRD2ESR1ESR2 | |
| SCHEMBL23921624 | 0.69 | HTR2A (0.43) | — | |
| SCHEMBL660714 | 0.69 | HTR2A (0.43) | — | |
| SCHEMBL15384214 | 0.69 | DRD2 (0.48) | DRD2HTR1AESR1ESR2 | |
| SCHEMBL1660087 | 0.69 | ADRA2A (0.50) | DRD2HTR1AESR1ESR2 | |
| SCHEMBL15576799 | 0.69 | KCNJ1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749001-A1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | Aventis Pharmaceuticals, Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005111025-A1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-11-24 | — | — | WO | disclosed |