Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504364 | 0.89 | CRBN (0.39) | PARP1POLBHTTESR2CRBN | |
| SCHEMBL5506130 | 0.88 | TSHR (0.42) | PARP1POLBHTTESR2CRBN | |
| SCHEMBL5499885 | 0.80 | HRH3 (0.41) | CRBN | |
| SCHEMBL5494260 | 0.79 | PARP1 (0.39) | PARP1POLBHTTESR2CRBN | |
| SCHEMBL4074754 | 0.77 | HTR3A (0.53) | — | |
| SCHEMBL5503804 | 0.73 | CDK4 (0.40) | CRBN | |
| SCHEMBL5507588 | 0.72 | CYP11B1 (0.50) | CYP11B2CYP19A1 | |
| SCHEMBL5501903 | 0.70 | TDP2 (0.41) | HTTCRBN | |
| SCHEMBL4077756 | 0.65 | HTR3A (0.50) | TSHRMAPK10 | |
| SCHEMBL4087446 | 0.65 | HTR3A (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737854-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | claimed |
| WO-2005100351-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | claimed |