Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 15/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 14/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.50 |
| ▸ | TDP2 | O95551 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499885 | 0.86 | HRH3 (0.41) | PDE3BPDE3A | |
| SCHEMBL5501903 | 0.86 | TDP2 (0.41) | TDP2CYP2C9 | |
| SCHEMBL5506130 | 0.83 | TSHR (0.42) | CYP11B1CYP11B2CYP19A1CHRNB2CHRNA3 | |
| SCHEMBL4074995 | 0.80 | CYP11B1 (0.49) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL5501479 | 0.72 | PARP1 (0.37) | CYP11B2CYP19A1 | |
| SCHEMBL4084284 | 0.71 | HTR3A (0.47) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL5504364 | 0.70 | CRBN (0.39) | — | |
| SCHEMBL5503804 | 0.69 | CDK4 (0.40) | — | |
| SCHEMBL6205709 | 0.68 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL23860769 | 0.67 | CRBN (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737854-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | claimed |
| WO-2005100351-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | claimed |