SCHEMBL5501540

SCHEMBL5501540

Cc1cccc(CC(N)c2ccccc2)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 5/20 0.53
TAAR1 Q96RJ0 4/20 0.47
SLC6A2 P23975 3/20 0.47
SLC6A4 P31645 2/20 0.47
SLC6A3 Q01959 2/20 0.47
MAOA P21397 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
CYP2A6 P11509 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA1 P30542 1/20 0.47
IDO1 P14902 2/20 0.46
CTSL P07711 1/20 0.44
CTSB P07858 1/20 0.44
CTSS P25774 1/20 0.44
USP2 O75604 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
HPN P05981 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3282110 0.89 TAAR1 (0.52) TACR1TAAR1SLC6A2SLC6A4SLC6A3
Aspartic Acid SCHEMBL11631107 0.85 SLC7A5 (0.45) CTSLCTSBCTSS
SCHEMBL3282306 0.83 PNMT (0.56) TACR1TAAR1SLC6A2SLC6A4SLC6A3
SCHEMBL3451169 0.80 EPHX1 (0.61) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL272604 0.80 EPHX1 (0.61) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL468022 0.80 EPHX1 (0.61) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL4987208 0.80 TACR1 (0.77) TACR1IDO1
SCHEMBL3283174 0.80 ACHE (0.48) TAAR1IDO1OPRM1
SCHEMBL23655308 0.80 AGXT (0.50) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL17196630 0.80 MAOA (0.55) TACR1TAAR1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144384-B1 COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2007-10-31 EP claimed
EP-0220435-A1 A method for preparing optically active half esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-05-06 EP disclosed
EP-0092194-A1 Method of obtaining optically active half esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-10-26 EP disclosed
US-4246424-A IN PRESENCE OF ALKALI METAL AND POLYCYCLIC AROMATIC HYDROCARBON SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-01-20 US disclosed
US-4162316-A ANALGESICS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1979-07-24 US disclosed
US-4158016-A CONTACTING WITH AN ALKALI METAL POLYCYCLIC AROMATIC HYDROCARBON CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-06-12 US disclosed
US-4080453-A ANALGESICS, ANTITUSSIVE DAINIPPON PHARMACEUTICAL CO., LTD. (JA) 1978-03-21 US disclosed