Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783101 | 0.97 | DRD2 (0.44) | DRD2DRD3LMNAGAAHTR6 | |
| SCHEMBL2781967 | 0.94 | NPC1 (0.40) | DRD2DRD3GAAHTR6DRD4 | |
| SCHEMBL2781214 | 0.85 | DRD2 (0.44) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL5519082 | 0.84 | DRD2 (0.45) | DRD2DRD3HTR6HTR2AHTR2C | |
| SCHEMBL5504103 | 0.84 | DRD2 (0.45) | DRD2DRD3HTR6DRD4NPC1 | |
| SCHEMBL2781951 | 0.83 | DRD2 (0.48) | DRD2DRD3LMNAGAAHTR6 | |
| SCHEMBL2783650 | 0.81 | DRD2 (0.48) | DRD2DRD3HTR6DRD4HTR1A | |
| SCHEMBL2782660 | 0.81 | DRD2 (0.48) | DRD2DRD3HTR6DRD4HTR1A | |
| SCHEMBL2781983 | 0.81 | MAPT (0.41) | DRD2DRD3GAADRD4NPC1 | |
| SCHEMBL2782487 | 0.81 | CHRM1 (0.45) | DRD2DRD3GAADRD4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |