Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782660 | 0.96 | DRD2 (0.48) | DRD2DRD3TTRHTR1ADRD4 | |
| SCHEMBL2782086 | 0.94 | TTR (0.46) | DRD2DRD3TTRNPC1RAB9A | |
| SCHEMBL5519082 | 0.88 | DRD2 (0.45) | DRD2DRD3ALDH1A1HTR2AHTR6 | |
| SCHEMBL5501574 | 0.84 | DRD2 (0.42) | DRD2DRD3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2783650 | 0.84 | DRD2 (0.48) | DRD2DRD3HTR1ADRD4ALDH1A1 | |
| SCHEMBL2782744 | 0.84 | DRD2 (0.52) | DRD2DRD3TTRHTR1ADRD4 | |
| SCHEMBL2784018 | 0.84 | DRD2 (0.48) | DRD2DRD3TTRHTR1ADRD4 | |
| SCHEMBL2784733 | 0.83 | DRD2 (0.60) | DRD2DRD3HTR1ADRD4HTR2B | |
| SCHEMBL2781571 | 0.82 | NPC1 (0.50) | TTRNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2783413 | 0.82 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |