Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783650 | 0.96 | DRD2 (0.48) | DRD2DRD3MAPTTP53HTR2A | |
| SCHEMBL2783413 | 0.94 | ALDH1A1 (0.44) | MAPTALDH1A1MEN1KMT2AREV1 | |
| SCHEMBL5504103 | 0.88 | DRD2 (0.45) | DRD2DRD3HTR2AHTR2CALDH1A1 | |
| SCHEMBL5501574 | 0.84 | DRD2 (0.42) | DRD2DRD3HTR2AHTR2CHTR6 | |
| SCHEMBL2782660 | 0.84 | DRD2 (0.48) | DRD2DRD3HTR2AHTR2CALDH1A1 | |
| SCHEMBL2782993 | 0.84 | DRD2 (0.44) | DRD2DRD3HTR2AHTR2CSLC6A4 | |
| SCHEMBL2784733 | 0.83 | DRD2 (0.60) | DRD2DRD3HTR2AHTR2CKCNH2 | |
| SCHEMBL2782086 | 0.82 | TTR (0.46) | DRD2DRD3ALDH1A1HTR6 | |
| SCHEMBL2783748 | 0.81 | DRD2 (0.52) | DRD2DRD3MAPTTP53HTR2A | |
| SCHEMBL2781614 | 0.81 | DRD2 (0.47) | DRD2DRD3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |