Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | HTR6 | P50406 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772149 | 0.96 | HTR6 (0.39) | DRD2HTR6MEN1KMT2AHTR1A | |
| SCHEMBL3772738 | 0.91 | DRD2 (0.45) | DRD2HTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL5504551 | 0.89 | DRD2 (0.39) | DRD2HTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL5511812 | 0.88 | DRD2 (0.38) | DRD2HTR6MEN1KMT2AHTR1A | |
| SCHEMBL5529625 | 0.85 | DRD2 (0.47) | DRD2HTR1ASLC6A4 | |
| SCHEMBL3778871 | 0.83 | SIGMAR1 (0.39) | DRD2MEN1KMT2AHTR1ADRD3 | |
| SCHEMBL2782269 | 0.82 | DRD2 (0.36) | DRD2MEN1KMT2AHTR1ADRD3 | |
| SCHEMBL3764817 | 0.82 | MEN1 (0.38) | DRD2MEN1KMT2AHTR1A | |
| SCHEMBL2781304 | 0.82 | DRD2 (0.36) | DRD2MEN1KMT2AHTR1ADRD3 | |
| SCHEMBL3766504 | 0.82 | DRD2 (0.59) | DRD2HTR6DRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768958-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-04 | — | — | EP | claimed |
| WO-2005121088-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |