Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378534 | 0.83 | PPARD (0.41) | PPARDPPARAPPARGTRPV1FFAR1 | |
| SCHEMBL5177050 | 0.79 | PKM (0.44) | PPARDPPARAPPARGTRPV1LMNA | |
| SCHEMBL1379245 | 0.77 | KDM4E (0.50) | PPARDPPARAPPARGTRPV1LMNA | |
| SCHEMBL5501943 | 0.77 | PPARG (0.47) | PPARDPPARAPPARGACACBFFAR1 | |
| SCHEMBL5176799 | 0.74 | PKM (0.44) | PPARDPPARAPPARGTRPV1LMNA | |
| SCHEMBL1384182 | 0.74 | FFAR1 (0.34) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL1378359 | 0.73 | PPARD (0.43) | PPARDPPARAPPARG | |
| SCHEMBL1378767 | 0.72 | MCL1 (0.42) | PPARDPPARAPPARGTRPV1ACACB | |
| SCHEMBL1380488 | 0.71 | GOT1 (0.43) | TRPV1LMNAMTNR1AMTNR1B | |
| SCHEMBL5177379 | 0.71 | PKM (0.44) | PPARDPPARAPPARGTRPV1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4629106-B2 | — | — | 2011-02-09 | — | — | JP | claimed |
| JP-2008509947-A | — | — | 2008-04-03 | — | — | JP | claimed |
| EP-1781608-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-09 | — | — | EP | claimed |
| WO-2006018174-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | claimed |