Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11304140 | 0.95 | CYP2C9 (0.54) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL4262556 | 0.84 | CYP1A2 (0.77) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL11597291 | 0.82 | CYP1A2 (0.59) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL21057241 | 0.82 | CYP1A2 (0.59) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL25212758 | 0.82 | CYP1A2 (0.59) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL6514898 | 0.81 | LDHA (0.58) | GAAEPHX2EPHX1ALDH1A1KMT2A | |
| SCHEMBL11304453 | 0.81 | PPARG (0.50) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL5206301 | 0.80 | KMT2A (0.60) | TDP1EPHX2PPARGPPARASMN1; SMN2 | |
| SCHEMBL11307361 | 0.80 | FPR2 (0.46) | CYP2C9CYP1A2GAAPKMCYP2C19 | |
| SCHEMBL5501943 | 0.80 | PPARG (0.47) | CYP2C9CYP1A2GAAPKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188263-B1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| US-7790904-B2 | Substituted benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090062356-A1 | SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062356-A1 | SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NR1H4, SLC10A1, FXR1 | CYP2C9 96/4885CYP1A2 205/4885GAA 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.