SCHEMBL5501971

SCHEMBL5501971

NS(=O)(=O)c1ccccc1[C]=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 14/20 0.60
CA9 Q16790 11/20 0.60
CA12 O43570 7/20 0.60
CA1 P00915 10/20 0.52
CA6 P23280 4/20 0.52
CA5A P35218 4/20 0.52
CA4 P22748 3/20 0.52
CA7 P43166 3/20 0.52
CA5B Q9Y2D0 3/20 0.52
CA14 Q9ULX7 2/20 0.52
CYP2C9 P11712 1/20 0.52
ALOX5 P09917 1/20 0.45
CA3 P07451 1/20 0.41
PLA2G7 Q13093 1/20 0.41
CA13 Q8N1Q1 1/20 0.41
LDHA P00338 1/20 0.41
CDK2 P24941 1/20 0.41
GAA P10253 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2468180 0.80 CA2 (0.58) CA2CA9CA12CA1CA6
SCHEMBL6342072 0.80 CA2 (0.58) CA2CA9CA12CA1CA6
SCHEMBL291455 0.80 CA2 (0.58) CA2CA9CA12CA1CA6
SCHEMBL29961798 0.80 CA2 (0.58) CA2CA9CA12CA1CA6
SCHEMBL15166880 0.77 ALDH1A1 (0.41) CA2CA9CA12CA1CA6
SCHEMBL5995711 0.77 ELANE (0.45) CA2CA9CA12CA1CA6
SCHEMBL998537 0.77 MYC (0.41) CA2CA9CA12CDK2GAA
SCHEMBL536000 0.77 PTGS2 (0.42) CA2CA9CA12GAAALDH1A1
SCHEMBL202947 0.77 CA2 (0.70) CA2CA9CA12CA1CA6
SCHEMBL9586213 0.77 CA2 (0.65) CA2CA9CA12CA1CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1343751-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-17 EP claimed
WO-2002060859-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2002-08-08 WO claimed
EP-1740574-A2 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES Otsuka Pharmaceutical Company, Limited (JP) 2007-01-10 EP disclosed
WO-2005105778-A2 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-11-10 WO disclosed
EP-1343751-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-17 EP disclosed
WO-2002060859-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2002-08-08 WO disclosed
WO-1998045231-A1 SUPPORTS FOR SOLID PHASE SYNTHESIS CADUS PHARMACEUTICAL CORPORATION (US) 1998-10-15 WO disclosed
US-4256752-A ANTIHISTAMINES, ANTISECRETORY AGENTS DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1981-03-17 US disclosed